Evaluation of an MRI-based protocol for cell implantation in four patients with Huntington's disease

Watts, C.; Donovan, Tim; Gillard, J.H.; Antoun, N.; Burnstein, R.; Menon, D.K.; Carpenter, T. Adrian; Fryer, T.; Thomas, D.G. and Pickard, J.D. (2003) Evaluation of an MRI-based protocol for cell implantation in four patients with Huntington's disease.

View this record at http://insight.cumbria.ac.uk/1036/
Official URL: 10.3727/000000003108747316

Abstract

The purpose of this study was to evaluate our surgical protocol for the preparation and delivery of suspensions of fetal tissue into the diseased human brain. We implanted suspensions of human fetal striatal anlage into the right caudate and putamen of four patients with Huntington's disease. Postoperative 3 tesla MR imaging confirmed accurate graft placement. Variability in graft survival was noted and the MR signal changes over 6 months revealed persistent hyperintense signal on T2-weighted images. Our results are consistent with those described by other groups and indicate that our surgical protocol is safe, accurate, and reproducible.

Item Type: Article
Keywords: 001 Knowledge, 616 Diseases & treatment (incl. counselling, radiography & medical imaging, critical & palliative care)
Members: University of Cumbria
Depositing User: ULCC Admin
Date Deposited: 22 Oct 2011 00:14
Last Modified: 03 Feb 2017 04:17
URI: http://collections.crest.ac.uk/id/eprint/2448

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