Autistic and Schizotypal Traits and Global Functioning in Bipolar I Disorder

Abu-Akel, A.; Clark, J.; Perry, Amy; Wood, S.J.; Forty, L.; Craddock, N.; Jones, I.; Gordon-Smith, Katherine and Jones, Lisa (2017) Autistic and Schizotypal Traits and Global Functioning in Bipolar I Disorder.

View this record at http://eprints.worc.ac.uk/4912/
Official URL: 10.1016/j.jad.2016.09.059

Abstract

Objective: To determine the expression of autistic and positive schizotypal traits in a large sample of adults with bipolar I disorder (BD-I), and the effect of co-occurring autistic and positive schizotypal traits on global functioning in BD-I. Method: Autistic and positive schizotypal traits were self-assessed in 797 individuals with BD-I recruited by the Bipolar Disorder Research Network. Differences in global functioning (rated using the Global Assessment Scale) during lifetime worst depressive and manic episodes (GASD and GASM respectively) were calculated in groups with high/low autistic and positive schizotypal traits. Regression analyses assessed the interactive effect of autistic and positive schizotypal traits on global functioning. Results: 47.2% (CI=43.7-50.7%) showed clinically significant levels of autistic traits, and 23.22% (95% CI=20.29-26.14) showed clinically significant levels of positive schizotypal traits. In the worst episode of mania, the high autistic, high positive schizotypal group had better global functioning compared to the other groups. Individual differences analyses showed that high levels of co-occurring traits were associated with better global functioning in both mood states. Limitations: Autistic and schizotypal traits were assessed using self-rated questionnaires. Conclusions: Expression of autistic and schizotypal traits in adults with BD-I is prevalent, and may be important to predict illness aetiology, prognosis, and diagnostic practices in this population. Future work should focus on replicating these findings in independent samples, and on the biological and/or psychosocial mechanisms underlying better global functioning in those who have high levels of both autistic and positive schizotypal traits.

Item Type: Article
Keywords: BF Psychology, RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Members: University of Worcester
Depositing User: ULCC Admin
Date Deposited: 08 Nov 2016 13:17
Last Modified: 08 Nov 2016 13:17
URI: http://collections.crest.ac.uk/id/eprint/14197

Actions (login required)

Edit Item Edit Item